Link to the clinic

The goal of this program is to facilitate the translation of fundamental science by identifying, stimulating and funding ideas with potential high value for patients. With expert support on exploratory development, we optimize (pre)clinical development plans. To support the programme, Oncode initiated two activities: the Clinical Proof of Concept fund and Clinical workshops.

Clinical Proof of Concept fund

The fund

Oncode aims to link fundamental and clinical research to enable efficient translation of promising research findings into novel diagnostic methods and clinical treatment strategies. To fund these projects, Oncode launched the Clinical Proof of Concept fund. Via a rolling call, Oncode Investigators - together with a clinician - can submit proposals to start (pre)clinical projects.

The Oncode approach

To support researchers in the development of their proposals, Oncode is offering extra support through the Oncode Exploratory Development Expert Support (OEDES) team. This team consists of experts in pre-clinical and clinical development, with experience in academic, industry and clinical settings. They help to define the goal of the study in relation to the overall development trajectory and can support researchers by giving them specific advice on their proposals, like pre-clinical requirements for safe and efficacious human dosing, validation strategies for new diagnostics and ways to maximize valuable results.

Procedure

Together with a clinician, Oncode Investigators can submit a pre-proposal (expression of interest), which will be reviewed by the Clinical Advisory Board (CAB), including a patient representative, the OEDES team, the Research Management Committee (RMC) and the Valorization team. After a positive outcome, the Investigator will be invited to prepare a full proposal. To support the researchers in putting together such a proposal and contribute with their specific expertise, they will be invited for an OEDES workshop. The full proposal will be reviewed by the CAB, OEDES and Valorization team, followed by a final decision of the Oncode Managing Board.

To fund these projects, Oncode launched the clinical proof-of-concept (cPoC) fund. Via a rolling call, Oncode Investigators can submit proposals to start clinical projects.

What are the eligibility criteria?

  • Projects must be tied to the main research focus of the applying Oncode Investigator.
  • Projects must involve at least one lead clinician, who may be associated with any Dutch institution.
  • Projects are either 1) clinical studies, i.e. studies in man or 2) pre-clinical studies of which the results, when positive, can lead directly to a clinical trial.
  • The project contains clear milestones with well-defined go/no- go criteria based on results that were obtained as well as on feasibility (patient accrual for example). The project can only proceed upon a positive decision based on these pre-defined go-criteria.
  • A total of up to 800.000 euros will be available for clinical studies (and studies with a strong clinical component as well as pre-clinical component). The detailed budget (full proposals) needs to indicate the amount required to achieve each of the milestones. Positive decisions based on the go/no-go criteria releases the subsequent parts of the allocated funding.
  • A total of up to 200.000 euros will be available for pre-clinical studies. The budget needs to indicate the amount required to achieve each of the milestones, and positive decisions based on the go/no-go criteria will release the subsequent parts of the allocated funding.

Clinical workshops

To facilitate the connection between the communities of basic and clinical researchers and clinicians, Oncode Institute organises regular clinical workshops around a specific tumor type.

The Oncode approach

One of the aims of Oncode Institute is to strengthen the link between fundamental and clinical research, with the ultimate goal of successfully translating fundamental research findings into clinical applications.

Therefore, Oncode is organizing a series of workshops to discuss challenges around a specific tumor type. The goals of these workshops are:

  1. Present the clinical practice, clinical needs and current trends in clinical research to Oncode Invetsigators.
  2. Present current trends in fundamental research to the clinical community.
  3. Explore together how fundamental research can address unmet needs and stimulate new collaboration projects that could be eligible for Oncode funding.

The audience for these types of workshops are academic researchers, clinical researchers, clinicians and some seats are available for industry (10%) within the specified research area. In order to stimulate discussion, the number of attendees is limited to 50-60.

Contact person

Marlinde Smit Programme Manager

Related news and events

Clinic
Two New Clinical Proof-of-Concept Projects Funded by Oncode Institute
Oncode Institute aims to link fundamental and clinical research to enable efficient translation of promising findings into novel diagnostic methods and clinical treatment strategies. We are pleased to announce that the 9th and 10th grant within the Clinical Proof of Concept programme have been awarded.
Bianca-OliviaNita
Else driehuis
Oncode Clinical Proof of Concept projects – status update
To support (pre)clinical projects, Oncode launched the Clinical Proof of Concept (CPoC) fund with an open call for proposals. One of the first projects that has received CPoC funding is ‘Head and neck cancer organoids and their potential to predict patient therapy response’ - a collaboration between the Hubrecht Institute, UMC Utrecht and Hubrecht Organoid Technology (HUB). We asked Else Driehuis - postdoc in Oncode Investigator Hans Clevers’ lab and Tech Transfer Scientist at HUB - about the progress and her experience with working on this project.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
20191104 Highlights of Oncodes Glioblastoma Workshop Card Image
Highlights of Oncode’s Glioblastoma Workshop
On October 16th 2019, Oncode held the second in the series of clinical workshops with the aim to strengthen the link between fundamental and clinical research.
Vesnade Jong

<span>Vesna</span><span>de Jong</span>

Vesna is a Digital Content Manager at Lygature, and is responsible for all things digital at Oncode. Originally from Slovenia, where she finished her MA in English language and literature, life led her to the Netherlands. Vesna has more than 10 years of experience in translation and localization, and has gained extensive experience of digital communications while working for one of the biggest online travel agencies.
20191101 TEIPP targeting immunotherapy project funded by Oncode Institute Card Image
TEIPP-targeting immunotherapy project funded by Oncode Institute
Oncode clinical Proof of concept Programme will fund the “TEIPP-targeting immunotherapy” project from Sjoerd van der Burg
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Crc Workshop 2
Learnings from the Oncode Colorectal Cancer workshop
To enhance the link between fundamental research and unmet needs in the clinic, Oncode is organizing a series of interactive workshops throughout the year. On Thursday 23 May we kicked off with the first one, focusing on colorectal cancer.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Clinic
Why clinicians and fundamental researchers need each other
Oncode Investigator Wilbert Zwart and Medical Oncologist André Bergman are interviewed on why clinicians and fundamental researchers need each other, and the value produced by such collaboration
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.