Link to the clinic
The goal of this program is to facilitate the translation of fundamental science by identifying, stimulating and funding ideas with potential high value for patients. With expert support on exploratory development, we optimize (pre)clinical development plans. To support the programme, Oncode initiated two activities: the Clinical Proof of Concept fund and Clinical workshops.
Clinical Proof of Concept fund
Oncode aims to link fundamental and clinical research to enable efficient translation of promising research findings into novel diagnostic methods and clinical treatment strategies. To fund these projects, Oncode launched the Clinical Proof of Concept fund. Via a rolling call, Oncode Investigators - together with a clinician - can submit proposals to start (pre)clinical projects.
The Oncode approach
To support researchers in the development of their proposals, Oncode is offering extra support through the Oncode Exploratory Development Expert Support (OEDES) team. This team consists of experts in pre-clinical and clinical development, with experience in academic, industry and clinical settings. They help to define the goal of the study in relation to the overall development trajectory and can support researchers by giving them specific advice on their proposals, like pre-clinical requirements for safe and efficacious human dosing, validation strategies for new diagnostics and ways to maximize valuable results.
Together with a clinician, Oncode Investigators can submit a pre-proposal (expression of interest), which will be reviewed by the Clinical Advisory Board (CAB), including a patient representative, the OEDES team, the Research Management Committee (RMC) and the Valorization team. After a positive outcome, the Investigator will be invited to prepare a full proposal. To support the researchers in putting together such a proposal and contribute with their specific expertise, they will be invited for an OEDES workshop. The full proposal will be reviewed by the CAB, OEDES and Valorization team, followed by a final decision of the Oncode Managing Board.
To fund these projects, Oncode launched the clinical proof-of-concept (cPoC) fund. Via a rolling call, Oncode Investigators can submit proposals to start clinical projects.
What are the eligibility criteria?
- Projects must be tied to the main research focus of the applying Oncode Investigator.
- Projects must involve at least one lead clinician, who may be associated with any Dutch institution.
- Projects are either 1) clinical studies, i.e. studies in man or 2) pre-clinical studies of which the results, when positive, can lead directly to a clinical trial.
- The project contains clear milestones with well-defined go/no- go criteria based on results that were obtained as well as on feasibility (patient accrual for example). The project can only proceed upon a positive decision based on these pre-defined go-criteria.
- A total of up to 800.000 euros will be available for clinical studies (and studies with a strong clinical component as well as pre-clinical component). The detailed budget (full proposals) needs to indicate the amount required to achieve each of the milestones. Positive decisions based on the go/no-go criteria releases the subsequent parts of the allocated funding.
- A total of up to 200.000 euros will be available for pre-clinical studies. The budget needs to indicate the amount required to achieve each of the milestones, and positive decisions based on the go/no-go criteria will release the subsequent parts of the allocated funding.
To facilitate the connection between the communities of basic and clinical researchers and clinicians, Oncode Institute organises regular clinical workshops around a specific tumor type.
The Oncode approach
One of the aims of Oncode Institute is to strengthen the link between fundamental and clinical research, with the ultimate goal of successfully translating fundamental research findings into clinical applications.
Therefore, Oncode is organizing a series of workshops to discuss challenges around a specific tumor type. The goals of these workshops are:
- Present the clinical practice, clinical needs and current trends in clinical research to Oncode Invetsigators.
- Present current trends in fundamental research to the clinical community.
- Explore together how fundamental research can address unmet needs and stimulate new collaboration projects that could be eligible for Oncode funding.
The audience for these types of workshops are academic researchers, clinical researchers, clinicians and some seats are available for industry (10%) within the specified research area. In order to stimulate discussion, the number of attendees is limited to 50-60.