Research Groups

Sjoerd van der Burg Group

Immunotherapy; T-cells; immune regulation; clinical trials

Our Focus

The white blood cells of the immune system play an important role in the outgrowth and elimination of cancer cells. Modulation of the immune system to treat cancer, also called immunotherapy, is currently regarded as the most innovative cancer therapy. My group “Experimental Cancer Immunology and Therapy” focuses on the factors of host-tumor interactions that determine the success and failure in immune control of cancer with the final aim to improve immunotherapeutic strategies against solid tumors.

We employ in vitro models, animal models and patient cohort studies to study the different molecular mechanisms that underlie the attraction, activation, suppression and antitumor efficacy of the different types of tumor-infiltrating immune cells, in particular T cells and myeloid cells. We want to understand how this is influenced by the tumor-immune context, the type of therapy (including chemotherapy, radiotherapy and targeted therapy) and the success of therapy achieved (cure, partial regression, stable disease).

Finally, we perform small clinical trials for first-in-man proof that newly designed strategies to positively influence the antitumor response work as we intended through comprehensive state-of-the-art immune monitoring.

Florine de Groot Phd Student
Nadine Pronk van Montfoort Junior Group Leader
Chantal Duurland Post Doc
Lien van der Minne Lab Manager
Camilla Labrie Technician
Elham Beyranvand-Nejad Phd Student
Jan-Willem Kleinovink Post Doc
Els Verdegaal Assistant Professor
Hella Pasmans Phd Student
Ilina Ehsan Technician
Vanessa van Ham Technician
Jim Middelburg Phd Student
Koen Marijt Phd Student
Kim Kortekaas Phd Student
Linda Borst Phd Student
Linda de Bruin Technician
Marij Welters Assistant Professor
Moniek van der Kooij Phd Student
Marjolein Sluijter Technician
Marit van Elsas Phd Student
Marten Visser Technician
Nikki Loof Technician
Christianne Groenveldt Phd Student
Priscilla Kinderman Technician
Sanne Boekestijn Technician
Saskia Santegoets Post Doc
Thorbald van Hall Assistant Professor
Contact Information
Sjoerd van der Burg Oncode Investigator

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