Peter ten Dijke Group

Mechanism of TGFb signalling

Our Focus

The Ten Dijke group is focused on TGF-β signaling dynamics during cancer progression in both cancer cells and neighbouring stroma, including cancer associated fibroblasts, blood and lymphatic vessels and immune cells. In particular, his laboratory is interested in how TGF-β switches from tumor suppressor at early stages into tumor promoter at late stages; how cancer cells loose the cytostatic response to TGF-β, but use SMAD and non-SMAD signaling pathways to mediate an epithelial to mesenchymal transition, invasion and metastasis of cancer cells. Insights into these mechanisms will be applied to develop therapeutic agents that selectively inhibit the pro-oncogenic effects of TGF-β.

Cancer cells that are treated by chemotherapy or by therapy targeting oncogenic signaling pathways frequently become resistant to therapy by over-activating TGF-β signaling. Thus, combinatorial treatment of such inhibitors with TGF-β inhibitors that target invasion, tumor angiogenesis or its immune suppression will be actively pursued, not only to obtain fundamental new insights, but for translation into the clinic.

Abhishek Sinha Postdoctoral Researcher
Chao Li Phd Student
Chuannan Fan Post Doc
David Baker Associate Professor
Dieuwke Marvin Phd Student
Gerardus van der Zon Technician
Jing Zhang Phd Student
Johannes van Dam Post Doc
Lizhe Zhu Phd Student
Maarten van Dinther Technician
Maureen Galmes-Spit Post Doc
Midory Thorikay Technician
Sudha Suriyamurthy Phd Student
Wang Haijiang Phd Student
Yuanzhou Gu Post Doc
Yang Hao Phd Student
Contact Information
Peter ten Dijke

Peter ten Dijke

Oncode Investigator



Oncode Investigator

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