Research Groups

Michiel Vermeulen Group

Proteomics & Chromatin biology

Our Focus

The development of an adult human being from a single fertilized egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 genes that the human genome encodes for. Cell-type specific gene expression patterns thus ensure the generation of hundreds of phenotypes based on a single genotype. Transcription factors play an important role in driving cell-type specific gene expression, but so-called epigenetic modifications of DNA and core histones also regulate changes in gene expression and phenotype during development and during adult life. Our lab is using state-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic regulation of gene expression in (differentiated) stem cells. Furthermore, we use the same technology to study deregulation of gene expression in cancer.

Cristina Furlan Post Doc
Ino Karemaker Phd Student
Lisa van Voorthuijsen Phd Student
Marijke Baltissen Technician
Matthew Makowski Phd Student
Nelleke Spruijt Post Doc
Pascal Jansen Technician
Rik Lindeboom Phd Student
Contact Information
Michiel Vermeulen Oncode Investigator

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