Maarten van Lohuizen Group

Transcriptional repression

Our Focus

Our lab has a long-standing interest in epigenetic gene regulation dictated by chromatin modifications. Main themes are to study the mechanism of stable inherited transcriptional repression by Polycomb-group (Pc-G) protein complexes, and the effects of deregulation of Pc-G genes on development, Cell cycle control, cancer formation and stem cell maintenance. In addition, we are performing large-scale genetic screens in primary cells and in cancer-predisposed mice to identify cancer-relevant combinations of collaborating oncogenes and tumor-suppressor genes.

Members
Maarten van Lohuizen

Maarten van Lohuizen

Oncode Investigator

 Oncode Investigator
Daniëlle Hulsman Technician
Gaurav Pandey Post Doc
Jasper van Genugten Phd Student
Jawahar Kopparam Post Doc
Jitendra Badhai Post Doc
Nick Landman Phd Student
Santiago Gisler Phd Student
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Contact Information
Maarten van Lohuizen

Maarten van Lohuizen

Oncode Investigator

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