Jop Kind Group

Spatiotemporal regulation of genomic function

Our Focus

The genomic era has greatly advanced our understanding of cellular processes and disease mechanisms. Yet, our knowledge about the regulation of the genome is generally based on datasets derived from large cell populations that provide an ensemble average interpretation of the biological system and disregard existing cell-to-cell heterogeneity.

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene-expression in single cells. We have developed a tool to image genome architecture in living cells and, more recently, a method to profile DNA-protein interactions at high resolution in single cells. With these techniques at our disposal, we aim to elucidate the role of genome architecture and chromatin context in regulating the temporal and spatial control of gene expression in development and disease.

Ellen Boele Technician
Franka Rang Phd Student
Isabel Guerreiro Post Doc
Kim de Luca Phd Student
Koos Rooijers Post Doc
Pim Rullens Phd Student
Robin van der Weide Post Doc
Ramada van Beek Research Technician
Silke Lochs Phd Student
Samy Kefalopoulou Phd Student
Sandra de Vries Technician
Contact Information
Jop Kind Oncode Investigator

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Research Strategy
Focus and Approach
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Our supporting programmes
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