Research Groups

Jop Kind Group

Spatiotemporal regulation of genomic function

Our Focus

The genomic era has greatly advanced our understanding of cellular processes and disease mechanisms. Yet, our knowledge about the regulation of the genome is generally based on datasets derived from large cell populations that provide an ensemble average interpretation of the biological system and disregard existing cell-to-cell heterogeneity. 

To uncover molecular processes in individual cells and to understand the full complexity of biological systems, our lab applies and develops novel microscopy and genomics based techniques to study the regulation of gene-expression in single cells. We have developed a tool to image genome architecture in living cells and, more recently, a method to profile DNA-protein interactions at high resolution in single cells. With these techniques at our disposal, we aim to elucidate the role of genome architecture and chromatin context in regulating the temporal and spatial control of gene expression in development and disease.  

Corina Markodimitraki Phd Student
Franka Rang Phd Student
Isabel Guerreiro Post Doc
Kim de Luca Phd Student
Koos Rooijers Post Doc
Leila Nahidiazar Post Doc
Silke Lochs Phd Student
Samy Kefalopoulou Phd Student
Sandra de Vries Technician
Sara Perricone Post Doc
Contact Information
Jop Kind Oncode Investigator

More Research

Research Strategy
Our Research Focus
Over 800 scientists working under a single strategy. Oncode is all about uniting efforts and bringing focus to research.
Support Programme
Research Programmes Overview
New plans that help fulfil Oncode's objectives get our full support. Young talents are matched with mentors on the basis of their personal endeavours.