Jarno Drost Group

Molecular dissection of childhood solid tumors

Our Focus

In the Western world, cancer is still the main cause of disease-related death among children. Many childhood solid tumors already originate in the developing fetus. They arise as a result of a block in processes driving lineage specification and differentiation during embryonic development. In most cases, the cells from which the tumors originate are only present during short, specific time windows. As a consequence, it is challenging to identify the processes initiating and driving the tumor. The Drost group studies childhood kidney and rhabdoid tumors and aims to understand their molecular and cellular identity.

For our research, we use primary patient material and stem cell culture models, such as patient-derived cancer organoids, in combination with (single-cell) sequencing and gene editing technologies. We are particularly interested in the (epi)genetic mechanisms driving renal and rhabdoid tumorigenesis. For instance, rhabdoid tumors are genetically “cold” tumors with only one recurrent driver mutation. Still, it is one of the most aggressive childhood cancers, which is most likely caused by epigenetic dysregulation. By understanding how these tumors develop during embryonic development and by performing high-throughput compound screens on patient-derived tumor organoids, we aim to find therapeutic opportunities to treat children with these currently untreatable tumors.

Arianna Fumagalli Post Doc
Dilara Ayyildiz Post Doc (bioinformatician)
Ewa Frazer Research Technician
Irene Paassen Phd Student
Juliane Buhl Post Doc
Jeff Demartino Phd Student
Jiayou He Phd Student
Marian Groot Koerkamp Research Technician
Mariel Brok Research Technician
M.P. Ganpat Maroussia Phd Student
Michael Meister Phd Student
Sofia Doulkeridou Research Technician
Terezinha de Souza Post Doc (bioinformatician)
Yvonne Tiersma Research Technician
Contact Information
Jarno Drost Oncode Investigator

More Research

Research Strategy
Focus and Approach
Over 800 scientists working under a single strategy. Oncode is all about uniting efforts and bringing focus to research.
Support Programme
Our supporting programmes
New plans that help fulfil Oncode's objectives get our full support. Young talents are matched with mentors on the basis of their personal endeavours.