Jacques Neefjes

Cell biology and cancer

Our Focus

Neefjes combines chemistry with cell biology and immunology with the aim to develop tools to manipulate the immune system and cancer biology. The work is focused on three areas:

Understanding the biology of MHC class I and MHC class II molecules

By combining genetic screens with chemical library screens both biology and chemical tools connected to the biology can be identified. The cell biology with have broad and sometimes defined consequences for various biological processes.

The contribution of bacteria in the development of tumors

This work is based on our original finding that AKT kinase was activated by bacteria such as Salmonella and M.tuberculosis to prevent their destruction in lysosomes. This yielded the first antibiotics acting on the infected host rather than pathogen. We subsequently showed that the same pathway contributed to the increased risk of gallbladder carcinoma with chronically infected typhoid carriers in India. We are combining cell biology with bacterial infection studies and epidemiology to find more relations between bacterial infections and cancer. These tumors can then be easily prevented.

The cell biology of anti-cancer drugs

We have focussed on the anthracycline class of drugs that are one of the most used drugs in oncology. We have identified a novel mode of action of these drugs; histone eviction which results in epigenetic modifications. We have both initiated a chemistry line to synthesize away some of the side effects of this drugs and a line of cell biology and genetics/bioinformatics to better understand the drugs. The aim is to find within the chemical space of these drugs new variants with unique effects both in the lab and –preferably- in the clinic.

Anneke Kastelein Phd Student
Allessio Ciurli Phd Candidate
Birol Cabukusta Post Doc
Daphne van Elsland Post Doc
Esther ter Linden Phd Student
Ilana Berlin Assistant Professor
Janneke Duijster Phd Student
Jimmy Akkermans Technician
Lennert Janssen Advisor
Merle van Gelder Phd Student
Marlieke Jongsma Post Doc
Priscillia Perrin Phd Student
Ruud Wijdeven Phd Student
Sabina van der Zanden Phd Student
Tom Schoufour Phd Student
Tom Cremer Phd Student
Virginie Stévenin Post Doc
Contact Information
Jacques Neefjes

Jacques Neefjes

Oncode Investigator

Oncode Investigator

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