Research Groups

Jan Paul Medema Group

Experimental Oncology and Radiobiology

Our Focus

My laboratory studies colon cancer from a heterogeneity point of view considering both the intra tumor heterogeneity that is defined by a CSC hierarchy as well as by clonal evolution and inter-tumor heterogeneity, which is defined by distinct subtypes as well as mutation profiles. 

We aim to understand not just the clinical implications, but more importantly the underlying biology that defines this heterogeneity in order to develop novel insight that could lead to therapy optimization. My laboratory is at the fore-front of CRC heterogeneity and specifically on how this affects cell death responses. Importantly, my lab is positioned centrally within several clinical departments (Surgery, Med Oncology, Pathology, Gastroenterology and Radiotherapy) and houses multiple clinical PhD students and projects from these departments. This translational collaboration allows us one hand to perform these biological pre-clinical studies on primary tumor material and to build pre-clinical models based on this patient material, but on the other hand also to couple our findings directly to clinical material and to serve as a starting point for clinical studies. 

I therefore believe that my unique contribution to cancer research is the linkage of fundamental insight into CRC heterogeneity and therapy response with clinical reality and therapeutic modalities.  

Alexander Kirov Phd Student
Amber van der Zalm Phd Student
Anne Steins Phd Student
Cansu Tekin Phd Student
Cynthia Waasdorp Technician
Danielle Dekker Technician
David Huels Post Doc
Dita Prasetyanti Phd Student
Gregor van Bochove Technician
Hans Rodermond Technician
Janneke Linnekamp Phd Student
Joan de Jong Technician
Joyce Buikhuisen Phd Student
Kate Cameron Technician
Larry Zhang Phd Student
Maarten Bijlsma Phd Student
Nesrin Tuysuz Post Doc
Paris Asif Phd Student
Patricia Gomez Phd Student
Prashanthi Ramesh Phd Student
Robin Blok Phd Student
Sander van Hooff Post Doc
Saskia van den Bergh Technician
Valerie Wouters Phd Student
Veerle Bosch Lammers Technician
Veronique Veenstra Phd Student
Contact Information
Jan Paul Medema Oncode Investigator

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