Research Groups

Geert Kops Group

Cell division & chromosome segregation

Our Focus

The human body is made up of trillions of cells that exist because of countless successful cycles of cell growth and division during embryo development. These cycles continue during our lifetime to produce cells for tissue renewal and repair. Uncontrolled cell division cycles, however, cause cancer. The Kops group aims to understand how normal division cycles produce healthy, genetically identical cells and how errors in this process contribute to cancer. 

We are particularly interested in the processes that ensure correct distribution of our genetic material, the chromosomes during cell division. This is not only fascinating from a molecular perspective (how does a cell do that) and an evolutionary perspective (How has this intricate process evolved and are there meaningful differences between species?) but also has implications for health and disease. Errors in chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant chromosome numbers, called aneuploidy. Finally, as we and others have shown, errors in chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and chromosome shattering (chromothripsis). 

For more information on our research, check out the video ‘Spying on cancer' and Geert Kops' profile on UU Life Sciences.

Ajit Quirindongo Technician
Ana Bolhaqueiro Phd Student
Anko de Graaff Microscope Facility Manager
Antoinette van den Dikkenberg Technician
Banafsheh Etemad Post Doc
Bas de Wolf Phd Student
Carlos Sacristan Lopez Post Doc
Claudia Rebel Technician
Eelco Tromer Post Doc
Enya Vermeulen MSc Student
Jingchao Wu Post Doc
Joris Treep Phd Student
Nannette Jelluma Post Doc
Pim Toonen Technician
Richard van Jaarsveld Phd Student
Sjoerd Klaasen Phd Student
Sonja Weterings MSc Student
Spiros Pachis Phd Student
Timo Kuijt Phd Student
Vincent Groenewold Technician
Wilma Hoevenaar Phd Student
Xiaorong Zhang Post Doc
Contact Information
Geert Kops Oncode Investigator

More Research

Research Strategy
Our Research Focus
Over 800 scientists working under a single strategy. Oncode is all about uniting efforts and bringing focus to research.
Support Programme
Research Programmes Overview
New plans that help fulfil Oncode's objectives get our full support. Young talents are matched with mentors on the basis of their personal endeavours.