The aim of our group is to understand genome function and dynamics. We want to understand the effect of non-coding genetic variation of gene expression. The majority of genetic variants associated with diseases and other traits are found in non-coding parts of the genome. We use high-throughput genomics tools and develop computational methods to identify genetic variants that play a causal role in gene expression.
In addition, we are interested how chromosomes are organized inside the nucleus. Chromosomes are centimeters long molecules that have to be fitted inside a micrometer sized nucleus. The folding of chromosomes is critically important for processes such as gene expression. We use and develop both computational and wet-lab methodology to better understand the interplay between the 3D genome and gene expression.