Bas van Steensel Group

Chromatin Genomics

Our Focus

Chromatin is probably the most complex molecular ensemble in the cell. It consists of hundreds of proteins that package the DNA and interact with regulatory elements such as enhancers and promoters. All of these components work in concert, and cannot be fully understood unless they are studied in their native context. In addition, the spatial organization of interphase chromosomes is thought to be of key importance for genome expression and maintenance. Yet, this three-dimensional chromosome organization and its impact on gene regulation and other functions are still poorly understood.

In order to gain insight into these fundamental processes, we develop and apply new genomics techniques to reveal the interplay of chromatin and regulatory elements, and to visualize the architecture of chromosomes inside the nucleus. Examples of such new techniques are our DamID and m6A-tracer methods to map and visualize protein - DNA interactions, the TRIP method for multiplexed measurements of chromatin context effects, and the TIDE method to quickly assess genome editing. We primarily use mammalian cultured cells as model systems.

Christine Moene Phd Student
Christ Leemans Phd Student
Ezequiel Miron Sardiello Post Doc
Jeremie Breda Post Doc
Lise Dauban Post Doc
Ludo Pagie Bioinformatician
Mathias Eder Phd Student
Max Trauernicht Phd Student
Marcel de Haas Technician
Miguel Martinez Ara Phd Student
Noud Klaassen Phd Student
Ruben Schep Phd Student
Stefano Manzo Post Doc
Tom van Schaik Phd Student
Xabier Vergara Ucin Phd Student
Contact Information
Bas van Steensel

Bas van Steensel

Oncode Investigator



Oncode Investigator

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