Wim Vermeulen Group

Wim Vermeulen

Oncode Investigator at Erasmus MC

My Research

Wim Vermeulen did his PhD on the genetic heterogeneity of DNA repair disorders in the laboratory of Prof. Dik Bootsma at the Erasmus University in Rotterdam. After his PhD in 1995 he started as a postdoc in the group of Jan Hoeijmakers at the department of Genetics of the Erasmus University where he discovered the tight connection between NER and transcription through the pivotal requirement of basal transcription factor TFIIH for NER. In 1999 he started as an independent researcher and pioneered the development and application of live cell imaging tools to quantitatively determine in vivo DNA repair kinetics (A.B. Houtsmuller, Science, 1999; D. Hoogstraten, Mol Cell, 2002).

Further highlights were: - the cloning and functional characterization of TFB5, a - at that time - newly identified TFIIH subunit in (Giglia-Mari, Nat Gen., 2004; - first identification of DNA damage-induced and NER-dependent H2A-ubiquitylation that functions in DNA damage signaling in 2006 (Bergink, G&D, 2006); - cell-type specific differential dynamic organization of TFIIH in different organs and tissues through the generation of fluorescent TFIIH (GFP-tagged subunit XPB) knock-in mouse-model (Giglia-Mari, PLoS Biol., 2009); - identification of developmental stage and differentiation-dependent differential NER organization in C.elegans (Lans, PLoS Gen., 2010); - identification of two novel TC-NER factors (Schwertman, Nat Gen., 2012); -identification of the ISWI chromatin-remodeling complex as a novel regulator of TC-NER (Aydin, NAR, 2014); - discovery of a new non-canonical ATM-mediated DDR signaling pathway, activated by R-loops that were formed by transcription-blocking DNA lesions (Tresini, Nature, 2015).

Awards

  • 2013: ERC Advanced Grant
  • 2004: ZonMW VIDI

Key Publications

  1. Aydin, Ö. Z., Marteijn, J. A., Ribeiro-Silva, C., Rodríguez López, A., Wijgers, N., Smeenk, G., ... & Lans, H. (2014). Human ISWI complexes are targeted by SMARCA5 ATPase and SLIDE domains to help resolve lesion-stalled transcription. Nucleic acids research, 42(13), 8473-8485.
  2. Lans, H., Lindvall, J. M., Thijssen, K., Karambelas, A. E., Cupac, D., Fensgård, Ø., ... & Vermeulen, W. (2013). DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals. Cell Death and Differentiation, 20(12), 1709.
  3. Marteijn, J. A., Lans, H., Vermeulen, W., & Hoeijmakers, J. H. (2014). Understanding nucleotide excision repair and its roles in cancer and ageing. Nature reviews Molecular cell biology, 15(7), 465.
  4. Schwertman, P., Lagarou, A., Dekkers, D. H., Raams, A., van der Hoek, A. C., Laffeber, C., ... & Marteijn, J. A. (2012). UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair. Nature genetics, 44(5), 598.
  5. Tresini, M., Warmerdam, D. O., Kolovos, P., Snijder, L., Vrouwe, M. G., Demmers, J. A., ... & Mullenders, L. H. (2015). The core spliceosome as target and effector of non-canonical ATM signalling. Nature, 523(7558), 53.
Contact Information
Wim Vermeulen

Wim Vermeulen

Oncode Investigator



Oncode Investigator

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