Marvin Tanenbaum Group

Marvin Tanenbaum

Oncode Investigator at Hubrecht Institute

My Research

Marvin Tanenbaum received his PhD (Cum Laude) in 2010 from Utrecht University for his work on cell division in the group of Prof. René Medema. During his PhD work, Marvin used live-cell microscopy to study the molecular mechanism of chromosome segregation during cell division. After obtaining his PhD, he received KWF and EMBO fellowships to perform his postdoctoral research in the group of Prof. Ron Vale at UCSF in the United States. As a postdoc, Marvin developed a keen interest in studying the control mechanisms and dynamics of gene expression in single cells, focusing on gene expression control during the cell cycle. He pioneered several new techniques using protein engineering that enabled direct observation of single protein molecules in action, and developed methods to observe gene expression in single living cells by fluorescence microscopy. He also developed a technique to modulate the activity of individual genes in single cells. In 2015, he became a group leader at the Hubrecht Institute. His group uses cutting edge, single molecule microscopy and novel types of genetic engineering to dissect the temporal and spatial control of gene expression.

Awards

  • 2017: HHMI International research scholar
  • 2015: ERC Starting grant
  • 2011: NVMO oncology thesis award
  • 2011: Girard de Mielet van Coehoorn Thesis Prize

Key Publications

  1. Jost, M., Chen, Y., Gilbert, L. A., Horlbeck, M. A., Krenning, L., Menchon, G., ... & Kampmann, M. (2017). Combined CRISPRi/a-based chemical genetic screens reveal that rigosertib is a microtubule-destabilizing agent. Molecular cell, 68(1), 210-223.
  2. Tanenbaum, M. E., Gilbert, L. A., Qi, L. S., Weissman, J. S., & Vale, R. D. (2014). A protein-tagging system for signal amplification in gene expression and fluorescence imaging. Cell, 159(3), 635-646.
  3. Tanenbaum, M. E., Stern-Ginossar, N., Weissman, J. S., & Vale, R. D. (2015). Regulation of mRNA translation during mitosis. Elife, 4.
  4. Tanenbaum, M. E., Vale, R. D., & McKenney, R. J. (2013). Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains. Elife, 2.
  5. Yan, X., Hoek, T. A., Vale, R. D., & Tanenbaum, M. E. (2016). Dynamics of translation of single mRNA molecules in vivo. Cell, 165(4), 976-989.
Contact Information
Marvin Tanenbaum Oncode Investigator

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