Jan Paul Medema Group

Jan Paul Medema

Oncode Investigator at AMC


  • 2009: Dutch Society of Gastroenterology Tytgat award
  • 2007: VICI laureate of the Dutch Science Organization
  • 2002: C.J.Kok prize
  • 2000: VIDI laureate of the Dutch Science Organization
  • 1996: Dutch Cancer Society Fellowship
  • Honorary Professorship Brunel University London, UK

Key Publications

  1. Felipe de Sousa, E. M., Colak, S., Buikhuisen, J., Koster, J., Cameron, K., de Jong, J. H., ... & Rodermond, H. (2011). Methylation of cancer-stem-cell-associated Wnt target genes predicts poor prognosis in colorectal cancer patients. Cell stem cell, 9(5), 476-485.
  2. Felipe De Sousa, E. M., Wang, X., Jansen, M., Fessler, E., Trinh, A., De Rooij, L. P., ... & Rodermond, H. (2013). Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions. Nature medicine, 19(5), 614.
  3. Kemper, K., Sprick, M. R., de Bree, M., Scopelliti, A., Vermeulen, L., Hoek, M., ... & Medema, J. P. (2010). The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer research, 70(2), 719-729.
  4. Medema, J. P. (2013). Cancer stem cells: the challenges ahead. Nature cell biology, 15(4), 338.
  5. Vermeulen, L., Felipe De Sousa, E. M., Van Der Heijden, M., Cameron, K., De Jong, J. H., Borovski, T., ... & Sprick, M. R. (2010). Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nature cell biology, 12(5), 468.
Contact Information
Jan Paul Medema Oncode Investigator

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