Hans Bos Group

Hans Bos

Chief Scientific Officer at Oncode Institute

My Research

Johannes L. (Hans) Bos started his career in 1975 in the lab of Piet Borst in Amsterdam as a PhD student working on mitochondrial DNA of yeast. After his PhD in 1980 he moved to the lab of Alex van der Eb in Leiden, and worked on the characterization of the E1 region of the oncogenic adenovirus 12. In 1984 he started to work on Ras mutations in human tumors.

After a sabbatical year in San Francisco with Frank McCormick he moved to Utrecht in 1991 to become professor in Molecular Cancer Research. In 2000 Hans Bos became director of the graduate school “Cancer, Genomics and Developmental Biology” and in 2007 chair of the Division Biomedical Genetics, both till 2015. He was also the director of the Cancer Genomics Center of the Netherlands Genomics Initiative and the Center for Biomedical Genetics, both national consortia for mainly molecular cancer research.

From 2015-2017 Hans Bos was chair of the Cancer priority program of the UMC Utrecht. Hans Bos has organized many scientific meetings, most notably from 1999 to 2015 the biannual Spetses summerschool on Molecular Mechanisms of Cancer. Hans Bos is one of the founding scientists of Oncode Institute and serves currently as (part-time) Chief Scientific Officer.


  • 2014: Josephine Nefkens Award
  • 2006: Appointed member of the Royal Netherlands Academy of Arts and Sciences
  • 1996: EMBO membership
  • 1986: C.J. Kok-Award. University of Leiden.

Key publications

  1. Bos, J. L. (1989). Ras oncogenes in human cancer: a review. Cancer research, 49(17), 4682-4689.

  2. Bruurs, L. J., Donker, L., Zwakenberg, S., Zwartkruis, F. J., Begthel, H., Knisely, A. S., ... & Bos, J. L. (2015). ATP8B1-mediated spatial organization of Cdc42 signaling maintains singularity during enterocyte polarization. J Cell Biol, 210(7), 1055-1063.

  3. De Rooij, J., Zwartkruis, F. J., Verheijen, M. H., Cool, R. H., Nijman, S. M., Wittinghofer, A., & Bos, J. L. (1998). Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature, 396(6710), 474.

  4. De Vries-Smits, A. M., Boudewijn, M. T., Leevers, S. J., & Bos, J. L. (1992). Involvement of p21ras in activation of extracellular signal-regulated kinase 2. Nature, 357(6379), 602.

  5. Post, A., Pannekoek, W. J., Ross, S. H., Verlaan, I., Brouwer, P. M., & Bos, J. L. (2013). Rasip1 mediates Rap1 regulation of Rho in endothelial barrier function through ArhGAP29. Proceedings of the National Academy of Sciences, 110(28), 11427-11432.

Contact Information
Hans Bos

Hans Bos

Oncode Investigator

Oncode Investigator

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