Anne Rios Group

Anne Rios

Oncode Investigator at Princess Máxima Center

My Research

Anne Rios received her PhD in 2011 for her research in developmental biology, most notably the identification of a novel scenario in which signals from migrating neural crest cells trigger fate decisions in stem cells. This work was initiated at the Institute of Marseille Luminy (IBDML) in Marseille, France and later continued at the Australian Regenerative Medicine Institute (ARMI) in Melbourne, Australia. After completing her PhD, Anne obtained a personal fellowship to perform postdoctoral research at the Walter and Eliza Hall Institute of Medical Research in Melbourne, Australia. During her postdoc she developed a novel 3D imaging methodology, allowing her to visualize intact tissue at single-cell resolution, which led to the first in vivo evidence of bipotent stem cells in the mammary gland. In addition, she applied this technology to breast cancer, revealing widespread clonal restriction during tumor progression.

In 2017, Anne was appointed junior principal investigator at the Princess Máxima Center for Pediatric Oncology and head of the Princess Máxima Imaging Center. Together with her team she keeps advancing imaging technology, as well as analytical methods to comprehend the large body of information retrieved from single-cell 3D imaging datasets. She applies these approaches to characterize and understand tumor heterogeneity, for instance in Wilm’s tumor, but also to study specific tumor cell behavior, such as the highly invasive nature of Diffuse Intrinsic Pontine Glioma. In addition, the behavior of immune cells is analyzed in projects aimed at understanding and potentially enhancing the tumor targeting behavior of cellular immunotherapies. Anne is a selected member of the Cancer Genomic Center (CGC) and next generation member of the International Society for Stem Cell Research (ISSCR). Anne received a European Research Council (ERC) Starting Grant and KWF high risk grant for her work on DIPG invasion, a CGC Young PI Award to study breast cancer dynamics and a St. Baldrick’s Robert J. Arceci Innovation Award recognizing her unconventional approach to pediatric cancer research. She has a strong passion for engaging the public and inspiring the future generation of scientists, which she aims to achieve through unique displays of her group’s 3D imaging data.

Awards

  • 2019: St. Baldrick’s Robert J. Arceci Innovation Award
  • 2018: ERC starting grant Deciphering and targeting the invasive nature of Diffuse Intrinsic Pontine Glioma
  • 2018: Villa Joep Optimizing neuroblastoma resection using fluorescent guided surgery
  • 2018: KWF high risk Unravelling the integration of pediatric high-grade glioma in the developing brain using state-of-the-art imaging
  • 2018: CGC young PI award Studying human breast cancer dynamics using multi-coloured lineage tracing
  • 2017: Cancer Genomic Center member
  • 2016: Lawrence Creative Prize Winner Medical Innovation Award
  • 2014: Walter and Eliza Hall Research Institute Post-Doctoral Award
  • 2013: Postdoctoral Fellowship co-funded by the National Breast Cancer Foundation and Cure Cancer Australia Foundation
  • 2011: Director’s Prize PhD award

Key Publications

  1. Rios AC, Serralbo, O., Salgado, D., Marcelle, C. (2011). Neural crest regulates myogenesis through the transient activation of NOTCH. Nature. 473(7348): 532-5; PMID: 21572437
  2. Rios AC*, Fu NY *, Lindeman GJ and Visvader JE. * Joint first authors In situ identification of bipotent stem cells in the mammary gland. Nature (2014), 506: 322-327; PMID: 24463516
  3. Fu NY*, Rios AC*, Pal B, Law C, Jamieson PR, Liu R, Vaillant F, Jackling F, Liu KH, Smyth GK,4,5 Lindeman GJ, Ritchie ME and Visvader JE. *Joint first authors. Identification of quiescent and spatially-restricted stem cells in the adult mammary gland. Nature Cell Biology (2017) 3:164-176; PMID: 28192422
  4. Rios AC*, Fu NY*, Jamieson PR, Pal B, Whitehead L, Nicholas KR, Lindeman GJ and Visvader JE. Essential role for a novel population of binucleated mammary epithelial cells in lactation. Nature Communications (2016);10.1038/ncomms11400; PMID: 27102712
  5. Rios AC, Clevers H. Imaging organoids: a bright future ahead. Nature Methods (2018) 3;15(1):24-26; PMID: 29298292
  6. Dekkers FD, Alieva M, Wellens LM, Ariese HCR, Jamieson PR, Vonk AM, Amatngalim GD, Hu H, Oost KC, Snippert HJG, Beekman JM, Wehrens EJM, Visvader JE*, Clevers H*, Rios AC*. *Joint senior authors. High resolution three-dimensional imaging of fixed an and cleared organoids. Nature Protocols 2019, 14(6):1756-1771; PMID 31053799
  7. Rios AC, Capaldo BD, Vaillant F, Pal B, van Ineveld R, Dawson CA, Chen Y, Nolan E, Fu NY; 3DTCLSM Group, Jackling FC, Devi S, Clouston D, Whitehead L, Smyth GK, Mueller SN, Lindeman GJ, Visvader JE. Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging. Cancer Cell2019, 35(6):953; PMID 30930118
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Anne Rios Oncode Investigator

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