Alexander van Oudenaarden Group

Alexander van Oudenaarden

Oncode Investigator at Hubrecht Institute

My research

Prof. dr. ir. Alexander van Oudenaarden is director and group leader at the Hubrecht Institute (KNAW) and professor of quantitative biology of gene regulation at the Faculty of Science and the Faculty of Medicine at Utrecht University. His research group works with advanced (light) microscopy and sequencing technologies in order to study individual cells. Van Oudenaarden studied materials science and physics at Delft, where he also obtained his PhD in solid state physics. As a postdoc he worked at Stanford University collaborating with Steven Boxer and Julie Theriot. He was professor of physics and biology at the Massachusetts Institute of Technology (MIT). In 2012 he moved to the Hubrecht Institute after 15 years in the USA. His group combines techniques – in part developed by themselves – from developmental biology, molecular biology, physics, mathematics and computer science. He was awarded the 2011 and 2016 ERC Advanced Investigator grant and in 2017 van Oudenaarden won the Spinoza Award.


  • 2017: Dutch Organization for Scientific Research (NWO) Spinoza Award
  • 2017: EMBO member
  • 2017: European Research Council (ERC) Advanced Grant
  • 2015: Member of Koninklijke Hollandsche Maatschappij der Wetenschappen (KHMW)
  • 2014: Member of the Royal Netherlands Academy of Arts and Sciences (KNAW)
  • 2012: European Research Council (ERC) Advanced Grant
  • 2012: Dutch Organization for Scientific Research (NWO) Vici Award
  • 2008: NIH Director’s Pioneer Award
  • 2008: Guggenheim Fellow
  • 2007: School of Science Prize for Excellence in Graduate Teaching
  • 2001: Keck Career Development Professor in Biomedical Engineering
  • 2001: Alfred Sloan Research Fellow
  • 2001: NSF CAREER award
  • 2000: Edgerly Science Partnership Award
  • 1998: Andries Miedema Award for best Ph.D.-research in the field of condensed matter physics in the Netherlands, awarded every other year by Fundamental Research on Matter (FOM).
  • 1998: Dutch Organization for Scientific Research (NWO) TALENT stipendium.
  • 1998: Ph.D. Applied Physics, cum laude.
  • 1994: Award for best undergraduate research in Materials Science, yearly award by Delft University of Technology.
  • 1993: M.S. Materials Science and Engineering, cum laude.

Key Publications

  1. Grün, D., Lyubimova, A., Kester, L., Wiebrands, K., Basak, O., Sasaki, N., ... & van Oudenaarden, A. (2015). Single-cell mRNA sequencing reveals rare intestinal cell types. Nature, 525(7568), 251.
  2. Schmiedel, J. M., Klemm, S. L., Zheng, Y., Sahay, A., Blüthgen, N., Marks, D. S., & van Oudenaarden, A. (2015). MicroRNA control of protein expression noise. Science, 348(6230), 128-132.
  3. Junker, J. P., Noël, E. S., Guryev, V., Peterson, K. A., Shah, G., Huisken, J., ... & van Oudenaarden, A. (2014). Genome-wide RNA tomography in the zebrafish embryo. Cell, 159(3), 662-675.
  4. Neuert, G., Munsky, B., Tan, R. Z., Teytelman, L., Khammash, M., & van Oudenaarden, A. (2013). Systematic identification of signal-activated stochastic gene regulation. Science, 339(6119), 584-587.
  5. Ji, N., Middelkoop, T. C., Mentink, R. A., Betist, M. C., Tonegawa, S., Mooijman, D., ... & van Oudenaarden, A. (2013). Feedback control of gene expression variability in the Caenorhabditis elegans Wnt pathway. Cell, 155(4), 869-880.
Contact Information
Alexander van Oudenaarden Oncode Investigator

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