News overview

Clinic
News
16 November 2021
Clinical trial with new lung cancer vaccine started
Last week a new clinical trial with a vaccine against non-small cell lung cancer started at Erasmus MC. The vaccine teaches the immune system of lung cancer patients to recognize and clear tumor cells. Developed in the lab of Oncode Investigator Sjoerd van der Burg at Leiden University Medical Center, the technology may offer relief to a large proportion of the nearly 10,000 patients who receive this diagnosis each year.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Picture2
News
10 November 2021
A wrap-up of the Clinical Workshop Melanoma: looking into present approaches and what the future looks like
Due to restrictions linked to the pandemic, the Clinical Workshop Melanoma had to be postponed from last year to October this year. The restrictions relaxed and finally being able to come together, the long-expected event could take place. We now look back at a successful workshop that took place on the 5th of October at the Oncode office in Utrecht. The goal of the event was to bring together clinicians and clinical and basic researchers to discuss the tumor type melanoma, and to discuss current trends and unmet needs both within the clinic and in (clinical) research. The workshop aimed to also explore how basic research can address these unmet clinical needs and to stimulate new collaborations through translational and clinical projects.
Bianca-OliviaNita

<span>Bianca-Olivia</span><span>Nita</span>

ONC Facilities Design 09
News
9 November 2021
Facility success stories: NKI Robotics and Screening Center
Investing in new technologies and facilities - which are available to all Oncode researchers - is one of the ways in which Oncode contributes to breakthroughs in cancer research. The Oncode drug screening centres of expertise at the LUMC and the NKI are examples of such facilities. They provide Oncode researchers with advice and support to perform complex compound screens with the Drug Repurposing library. Researcher Przemek Krawczyk discusses his experiences so far.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Inmemoriam
News
28 October 2021
In memoriam: Boelien Geerts
Sadly, we received the news that Boelien Geerts, one of the first patient representatives of Oncode’s Patient Engagement Programme, passed away on October 14 from the effects of lung cancer. Her absence will certainly be felt. We can openly say that Boelien was very active and committed to Oncode Institute’s efforts and mission. She contributed to our Patient Engagement Programme and inspired our researchers through her novel ideas, perspectives, and discussions based on her personal experiences and knowledge, and driven by a lot of enthusiasm.
Bianca-OliviaNita

<span>Bianca-Olivia</span><span>Nita</span>

David livingston
News
21 October 2021
In memoriam: David Morse Livingston, MD
Oncode Institute and its research community were saddened by the news of the unexpected death of David M. Livingston, MD. Livingston was the Deputy Director of the Dana-Farber/Harvard Cancer Center; Chief of the Charles A. Dana Division of Human Cancer Genetics, and the Emil Frei Professor of Genetics and Medicine at Harvard Medical School. He was also the chair of Oncode’s International Advisory Board.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Intellectual property
News
21 October 2021
Oncode Institute supports new preclinical collaboration between HepaRegeniX and the NKI
HepaRegeniX GmbH, a clinical stage company developing novel therapies for the treatment of acute and chronic liver diseases, announced a collaboration with the NKI to investigate HepaRegeniX’ new drug candidate HRX-0233 in preclinical in vivo models with Kirsten rat sarcoma virus (KRAS) mutant tumors. Oncode’s Valorization Team supported the contract negotiations.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Picture1
News
19 October 2021
New research uncovers growth dynamics of pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease and patients diagnosed with PDAC have a very poor prognosis. It has been speculated that a rare population of cancer stem cells (CSCs) are responsible for tumor growth, therapy resistance, and rapid metastatic progression in PDAC. The purported CSC populations were discovered by in vitro clonogenic assays and transplantation assays in mice. However, their relevance in established PDAC tissue has not been determined. Importantly these assays were mostly dependent on the expression of a specific marker, therefore the functionality of cell populations not expressing these markers remained untested. A new study by Oncode Investigator Louis Vermeulen and co-investigators Sophie Lodestijn and Maarten Bijlsma (all Amsterdam UMC), published today in Cell Reports, changes that. Their results can have important implications for the treatment of PDAC.
Bianca-OliviaNita

<span>Bianca-Olivia</span><span>Nita</span>

Screenshot 2021 10 12 at 17 16 36
News
12 October 2021
“I need to know that what I do matters”
Despite her busy schedule, physician-scientist, gastroesophageal cancer specialist and Oncode Investigator Sarah Derks (Amsterdam UMC, VUmc site) took time out to participate in the Darm to Darm cycling challenge: a charity biking race from Amsterdam to Darmstadt (Germany). What motivated her to do so, and what makes her tick both professionally and personally?
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
2by3 Birnstiel2021 Announcement
News
1 October 2021
Two Oncode researchers win the International Birnstiel Award
Oncode Institute is proud to announce that two Oncode researchers have won the 2021 International Birnstiel Award for Doctoral Studies in Molecular Life Sciences. Sanne Boersma (Hubrecht Institute, Marvin Tanenbaum Group) and Sanne van Neerven (Amsterdam University Medical Center, Louis Vermeulen Group) are among the six winners this year.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
20210921 162125
News
30 September 2021
Science meets forest in the heart of the Netherlands: highlights of Oncode’s first Postdoc Retreat
Here is a recipe: take a group of postdoc researchers from different Oncode labs and bring them to De Werelt, this beautiful and calm location in the middle of the Netherlands, surrounded by forest. Have them stay for two days. Add scientific sessions covering a wide variety of topics and alternate with collaborative pitches for participants. Add two keynote lectures, a debate, a poster session and an extensive workshop on Intellectual Property and Entrepreneurship as well. Season it all with exploratory career discussions, with five different guests working in different fields. Finally, mix in lots of breaks for informal talks and networking. The result is Oncode’s first Postdoc Retreat that took place last week.
Bianca-OliviaNita

<span>Bianca-Olivia</span><span>Nita</span>

Beast
News
28 September 2021
History of successful STRIP consortium published in Nature Biotechnology
In March 2020, Oncode Investigators Marvin Tanenbaum and Wouter de Laat (group leaders at the Hubrecht Institute) brought together a large group of researchers at the Hubrecht Institute to support the Netherlands in fighting the COVID-19 pandemic. At that time, testing for COVID was extremely difficult. The researchers got in touch with scientists at Genmab, specialists in molecular biology automation, and together started the STRIP consortium. STRIP developed and implemented a test robot (lovingly called ‘the Beast’) with the capacity to make PCR testing possible on a much larger scale and more cost effective. The test protocol, as well as a history of this extraordinary consortium, is now published in Nature Biotechnology.
ElizeBrolsma

<span>Elize</span><span>Brolsma</span>

Elize is part of Oncode’s communication team. She has over 10 years of experience in the com-munication industry, both for commercial and non-profit organisations. After obtaining her bache-lor and master degree in communication at Utrecht University, Elize worked as a communication professional at a research institute, PR agency, law firm and internet company. She has a strong focus on external communications and Public Relations. At Oncode - together with her colleagues - Elize produces the monthly newsletters for Oncode Investigators & Researchers and the Oncode digital magazine. She publishes content for the Oncode website and is responsible for all social media channels. She enjoys discussing science with researchers and support them in their outreach.
Picture 1b
News
28 September 2021
Paving the way for treatment of AML patients with EVI1 gene expression
Amongst AML (acute myeloid leukemia) patients, a subgroup in which the EVI1 gene is overexpressed has a very poor outcome, with low response to treatment and a high need for new treatment strategies. The activation of this oncogene is caused by chromosomal rearrangements on the long arm of chromosome 3. The exact mechanism was however unclear. Previous work from Oncode Investigator Ruud Delwel’s group at Erasmus MC showed that in both inv(3)/t(3;3) as well as other 3q26 rearranged AMLs, an enhancer is hijacked and drives oncogenic expression of EVI1. Now two new manuscripts of his group, of which one published today in Nature Communications, report on the mechanisms that cause overexpression of this EVI1 oncogene, which may provide new angles to identify strategies to modulate EVI1 expression for treatment of AML.
Bianca-OliviaNita

<span>Bianca-Olivia</span><span>Nita</span>