26 July 2019

New vacancies at Oncode Partner Institutes

Elize Brolsma

Research Technician Immunology / UMC Utrecht

Your challenge:
The Linde Meyaard Group is expanding its efforts to identify and characterize novel inhibitory receptors. For this project, they will need to validate protein expression and function of multiple putative inhibitory receptors. You will be responsible for the generation of tools such as recombinant proteins, antibodies, etc, to study these receptors. For this, you will work independently and collaborate with multiple scientists in our team . Experience with molecular techniques (cloning), and ÄKTA are a pre-requisite.

Your profile:
Trained at HLO (hoger laboratorium onderwijs; university of applied sciences) level, or equivalent. Experience in molecular cloning and protein purification. Work independently and on multiple projects at the same time. Communicate in English at a sufficient level to discuss your results and follow-up plans.

Preferred skill: Affinity with immunology
Desired skill: Permit to perfom animal experiments, and the willingness to do so.

Find the complete vacancy here: https://www.werkenbijumcutrech...

More information:
If you have any questions about this vacancy, please contact Mr. Michiel van der Vlist, Senior Postdoc, phone number: 0887550874, e‑mail adress: mvlist2@umcutrecht.nl.

You can apply until Septmeber 1st 2019

---------------

Postdoctoral research / Cell and Chemical Biology / Leiden University Medical Center

Your challenge:
Perturbation in transforming growth factor-b (TGF-β) signalling can induce cancer cell invasion and metastasis and immune evasion. To restore the balance we want to develop synthetic bioactive molecules that selectively modulate protein-protein interactions or enzymatic activities involved in TGF-b signaling. Examples of such molecules with therapeutic potential include nanobodies, macrocyclic kinase inhibitors, PROTACs (Proteolysis targeting chimeric molecules) and inhibitors of deubiquitinating enzymes.

Your profile:
A highly motivated scientist with proven research abilities to work independently and as part of a team. You should hold a PhD in chemical biology or molecular cell biology, and have a strong background in signal transduction. You enjoy challenges and working in a multidisciplinary and internationally oriented work environment.

Check out the group web site: https://ccb.lumc.nl/about-the-...

Find the complete vacancy here: https://ccb.lumc.nl/vacancies-...

More information:
If you are interested in this position, please contact Dr. Peter ten Dijke, via telephone number +31-71-5269271 or e-mail p.ten_dijke@lumc.nl

You can apply until August 31st 2019

-----------------------------

Postdoctoral research / Cell and Chemical Biology / Leiden University Medical Center

Your challenge:
Perturbation of transforming growth factor-b (TGF-β) signalling can induce cancer cell invasion and metastasis and immune evasion. We have performed genetic, chemical and proteomic screens and identified novel and critical regulators of TGF-β signalling pathways. In this project their mechanism of action and importance in cancer progression will be elucidated. In addition, we will harness the ubiquitin machinery (e.g. using PROTACs) to induce degradation of critical pro-oncogenic factors.

Your profile:
An enthusiastic scientist with a drive to answer important fundamental and biomedical research questions. You should hold a PhD in life sciences and have a strong background in signal transduction or chemical biology. You enjoy challenges and working in a multidisciplinary and internationally oriented work environment.

Check out the group web site: https://ccb.lumc.nl/about-the-...

Find the complete vacancy here: https://www.lumc.nl/over-het-l...

More information:
If you are interested in this position, please contact Dr. Peter ten Dijke, via telephone number +31-71-5269271 or e-mailp.ten_dijke@lumc.nl

You can apply until August 31st 2019

--------------------------

Postdoctoral researcher | Medical oncology | Amsterdam UMC, location VUmc

Your challenge
The research group takes multiple efforts to understand resistance to therapy and develop novel treatment strategies in gastro-esophageal adenocarcinoma (GEA). They have recently identified that one of the central problems in GEA treatment is the existence of excessive intratumor genomic heterogeneity.

This profound heterogeneity explains why often only partial responses are achieved by neoadjuvant therapy. To understand GEA intratumor heterogeneity and identify drivers and mechanisms of therapy resistance, the group aims to build patient-derived models of therapy unresponsive patients and use these to development novel treatment strategies.

Your profile
An enthousiastic post-doc with a PhD in cancer genomics or immunology with a medical or biological background. Affinity/experience with organoid modeling or immunological assays is needed. Bioinformatic skills are a great plus. You are a team-player with excellent communication skills. You enjoy a challence and have experience with working in a multidisciplinary and internationally oriented work environment.

Check out the complete vacancy here: https://www.werkenbijvumc.nl/v...

More information:
If you’re interested about this position, you can contact Dr. Derks, via telephone number (+31)20 444 3210.
If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at (+31)20 444 5635.

You can apply untill August 19, 2019

Other News

NH20201125 016
Biotech Wednesday – Spotlight on Cancer Treatments for the 21st Century
The second edition of Biotech Wednesday, an event organized by Oncode Institute in collaboration with HollandBio, switched locations, from Pakhuis de Zwijger to the online. What seemed at first a limitation turned out to be an opportunity. With a line-up of top speakers from both research and industry, and participants joining the event from 14 countries spread on three continents, this year’s digital edition of Biotech Wednesday was a success.
Bianca-OliviaNita
Quarterly Dec2020
The December edition of Oncode’s digital magazine is here
Welcome to the last 2020 issue of Oncode’s digital magazine. As this unusual year comes to an end, December is the month to look back and forward.
Vesnade Jong

<span>Vesna</span><span>de Jong</span>

Vesna is a Digital Content Manager at Lygature, and is responsible for all things digital at Oncode. Originally from Slovenia, where she finished her MA in English language and literature, life led her to the Netherlands. Vesna has more than 10 years of experience in translation and localization, and has gained extensive experience of digital communications while working for one of the biggest online travel agencies.
Thumbnailt5Gr2Nz3
A brand new video series about the Clinical Proof of Concept landscape
As part of the Clinical Proof Concept programme, the Oncode Exploratory Development Expert Support (OEDES) team has created a video series wherein they take you on an informative journey through the landscape of Clinical Proof of Concept. In this way, the OEDES team provides guidance and advice for Oncode Investigators and Researchers when it comes to translating our fundamental scientific insights into new diagnostics and therapeutic strategies.
Bianca-OliviaNita