27 May 2020

New facilities available for Oncode researchers

Elize Brolsma

We are pleased to announce that three facilities are now open to the whole Oncode research community. The goal of Oncode Institute is to translate the results of ground-breaking fundamental research into the clinic faster, in order to improve the chances of cancer patients. Instead of competition between scientists, Oncode encourages collaboration. Investing in facilities which can be used by all Oncode researchers, is one of the ways in which Oncode wants to contribute to breakthroughs in cancer research.

Proteomics for Oncode
Location: UMC Utrecht
Contact persons: Boudewijn Burgering and Michiel Vermeulen
Diseases such as cancer are characterized by cellular heterogeneity. This facility offers a state-of-the-art proteomics by measuring the full protein and/or metabolite composition. In the future this facility will be complemented with single cell proteomics.

Location: NKI
Contact person: Anastassis Perrakis
The Protein Facility will support Oncode researchers with expressing and purifying proteins, characterising them (quality control), and crystallising them for X-ray analysis. This facility can also help researchers measure their interactions with other proteins, nucleic acids, lipids, carbohydrates, and small molecules. Finally, the facility supports in setting up and optimising activity assays.

Oncode Antibody biologics accelerator platform UMAB
Location: UMC Utrecht
Contact person: Linde Meyaard and Jeanette Leusen
The goal of this facility is to work closely with researchers to develop new monoclonal antibodies, suited for specific basic research or clinical applications. UMAB employs a new and very efficient cellular immunization method in mice. With this method, antibodies can be raised against for instance low immunogenic membrane proteins. In addition, UMAB can make antibodies against conformational epitopes and generate agonistic and antagonistic antibodies.

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