7 September 2021
Evidence for safety: stem cell transplants do not lead to changes in the DNA
A new study from the group of Oncode Investigator Ruben van Boxtel shows that stem cell transplants do not lead to changes in the DNA of the donor cells. This conclusion provides important evidence for the safety of this procedure. Stem cell transplants can form part of the treatment for children with certain types of leukemia.
1 September 2021
Oncode Institute co-lead of major consortium studying therapy resistance in cancer
90% of people who die from cancer respond well to the first treatment, but the cancer is fatal upon its return. In these cases, the tumor has often become resistant to the treatment that initially worked. PERSIST-SEQ, a new international consortium of academic and industry experts in cancer research, will spend the next 5 years intensively investigating why cancer often returns after treatment.
26 August 2021
The added value and simplicity of data management: the how, the why and what sound data management can bring to your lab
Making it transparent, reproducible, re-usable – the benefits of good data management are manifold. In Monique den Boer’s lab at the Princess Máxima Center for pediatric oncology, the structured practices of data management are now part of the lab’s culture. This has brought not only a wealth of data that everyone can use, but also various international collaborations and publications. We spoke to Judith Boer, long-time data steward within the lab, about the easy but efficient structure she devised and implemented, and the challenges and long-term benefits of storing data well.
9 August 2021
New research reveals that the actionable metastatic cancer genome is remarkably stable
A one-time analysis of the entire tumor DNA is almost always sufficient to find all DNA errors that may be relevant for treating metastatic cancer. This is because actionable DNA errors remain remarkably stable over time, despite treatment with drugs. This discovery was made by Oncode Investigator Emile Voest (NKI) and his team at the Netherlands Cancer Institute, with the financial support of Oncode Institute. Their findings are now published in Nature Medicine.
5 August 2021
Absence of stem cells in pancreas changes view on pancreatic cancer
New research by Oncode Investigator Louis Vermeulen and co-investigator Maarten Bijlsma shows that there are no stem cells in the pancreas. These unexpected findings potentially have major implications for pancreatic cancer research, since stem cells are often at the root of tumor development. This research was published today in the leading journal Cell Stem Cell.
27 July 2021
Antibodies with a mission: what the Utrecht Monoclonal Antibody Facility (UMab) can do for you
As part of the Infrastructure and Technology programme, Oncode started a collaborative project together with Oncode Investigator Linde Meyaard (UMCU) and Jeanette Leusen (head of the Utrecht Monoclonal Antibody Facility (UMab)) with the goal of being able to offer Oncode Investigators the opportunity to produce high quality antibodies (targeted against membrane proteins). Oncode is now looking to fund a total of 4 Oncode Investigators to develop monoclonal antibodies potentially suited for clinical applications in oncology, directed against their membrane target of choice.
In the spotlight
22 July 2020
COVID-19: updates for the Oncode research community
As an Oncode researcher, you might have questions about how we are mitigating the impact of the current COVID-19 crisis on our programmes, projects and funding. We created a Q&A with the answers these questions and plan to update this Q&A regularly.
20 July 2021
Oncode collaboration results in a new mathematical method that can predict cancer survival based on genetic changes
As cancer survival rates vary widely, Oncode Researcher Daniel Miedema from Oncode Investigator Louis Vermeulen’s lab (Amsterdam UMC), in collaboration with the teams of Oncode Investigators Hugo Snippert (UMC Utrecht) and Geert Kops (Hubrecht Institute) has developed a mathematical method to predict survival based on genetic changes in cancer. The results of this study are now published in Nature Communications.
14 July 2021
Oncode Investigators Hugo Snippert and Jarno Drost receive NWO-Vidi grant
Just announced: The Dutch Research Council has awarded Oncode Investigators Hugo Snippert (UMCU) and Jarno Drost (Princess Máxima Center for pediatric oncology) a NWO-Vidi grant worth 800.000 Euros. The Vidi grant is part of the NWO Talent Programme and will enable them to develop their own innovative line of research in the coming five years.
12 July 2021
Oncode and NKI spinout a new company targeting senescence in oncology, led by Rene Bernards
Over the last 5 years Oncode Investigator Rene Bernards’ laboratory at the NKI has been focused on understanding senescence and its role in tumour biology. This has now culminated in a new company that will take the next step – discover and develop therapeutics that exploit senescence to target tumours.
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